Clozapine FDA Link Generic

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Also Known As:

Clozaril; Leponex; 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-

Pharmalogical Action Categories:

Antipsychotic Agents
GABA Antagonists
Serotonin Antagonists

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzazepines: 4
      - Clozapine: 6796

Andrew C Martina Selected Research

Andrew C Martina Research Topics

Disease

Drug/Important Bio-Agent (IBA)